Haroutiunian S 2009: Valproic acid plasma concentration decreases in a dose-independent manner following administration of meropenem: a retrospective study
Gu J 2009: Effect of concomitant administration of meropenem and valproic acid in an elderly Chinese patient.
San Antonio Arce V 2009: Meropenem y ácido valproico: una interacción a recordar
Tobin JK 2009: Valproic acid-carbapenem interaction: report of six cases and a review of the literature
Lee SG 2007: [Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics]
Mori H 2007: Interaction between valproic acid and carbapenem antibiotics.
Lunde JL 2007: Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy
Nacarkukuk E et al: Meropenem decreases serum level of valproic acid. 2004
WHO Pharmaceutical Newsletter 3, 2010, Seite 7
Zum möglichen Wirkmechansimus:
Suzuki E 2010: Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics
Mancl EE 2009: The effect of carbapenem antibiotics on plasma concentrations of valproic acid
Desai J: Perspectives on interactions between antiepileptic drugs (AEDs) and antimicrobial agents. 2008
Nakajima Y et al: Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats. 2004.
Siehe auch Arzneimittelkompendium der Schweiz sowie Fachinformation (D) und Ami-Info.at (A) oder Online Suche Arzneispezialitäten (A)
